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Comparison of Moringa oleifera Leaves Extract with Atenolol on
Serum triglyceride, Serum Cholesterol, Blood glucose, heart weight, body weight
in Adrenaline Induced Rats
Naznin Ara1, Mamunur Rashid1 and Md. Shah Amran2
1Department of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi
6205, Bangladesh.
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of
Dhaka, Dhaka-1000, Bangladesh
Abstract
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The research work was investigated to compare the effects
of Moringa oleifera with atenolol on serum cholesterol level, serum
triglyceride level, blood glucose level, heart weight and body weight of
adrenaline induced rats (AIR) in a crossover design. The
pharmacologically active components responsible for above-mentioned
activities were isolated from plant using bioassay guided purification
approach and the structures of the compounds were proposed by the
spectroscopic methods. Moringa oleifera leaves extract and commercial
drug atenolol were administered in adrenaline induced rat through
intraperitoneal (i.p) route in everyday morning for one week at a dose
30mg/155±15-gm.body weight and 0.1 mg/155±15-gm.body weight of rat
respectively. Different biochemical parameters such as heart weight,
blood glucose level, serum cholesterol level, serum triglyceride level,
body weight and the relationship between them were measured. The dose of
the marketed drug atenolol was determined according to the previous
knowledge of its pharmacokinetic parameters. Clinically effective plasma
concentration as a hypotensive drug was obtained after the injection of
0.1 mg /155±5 gm body weight of drug. The Moringa oleifera leaves
extract made significant changes in each cardiovascular parameter after
proper investigation. From the present study we revealed that the leaves
extracts of Moringa oleifera with atenolol has got profound
hypolipidemic (Figure 3) activity. Lowering of blood glucose, heart
weight, and body weight (Figure 1,2 and 4) in adrenaline induced rats (.
p<0.0001) was significant. The lowering serum triglyceride level and
serum cholesterol level between leaves extract of Moringa oleifera and
atenolol in adrenaline induced rats was very significant (p<0.001 &
p<0.01).
Key words: Serum triglyceride, Serum cholesterol, Moringa oleifera,
atenolol, adrenaline, and heart weight
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